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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-127@lptms.universite-paris-saclay.fr
DTSTART:20130628T140000Z
DTEND:20130628T140000Z
DTSTAMP:20130628T082908Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-abdul-barakat/
SUMMARY:Physics-Biology interface seminar : Abdul Barakat - Moyen Amphi\, B
 uilding 510\, Université Paris-Saclay Orsay - 28 Juin 13 14:00
DESCRIPTION:Mechanotransduction in Vascular Endothelial Cells: Mechanisms a
 nd Implications\nAbdul Barakat (École Polytechnique)\nThe ability of arte
 rial endothelial cells\, the cells lining the inner surfaces of blood vess
 els\, to respond to mechanical forces associated with blood flow is essent
 ial for normal vascular function. Abnormalities in endothelial cell mechan
 otransduction play a critical role in the development and progression of c
 ardiovascular disease. The mechanisms governing how endothelial cells sens
 e mechanical forces on their surfaces and how they subsequently transmit t
 hese forces within the intracellular space remain poorly understood. In th
 is talk\, I will present experimental and computational results in support
  of a central role for the cellular cytoskeleton in force transmission wit
 hin endothelial cells. Because endothelial cells are often simultaneously 
 exposed to multiple biophysical stimuli\, I will show data that demonstrat
 e that endothelial cells integrate biophysical stimuli derived from simult
 aneous apical cellular stimulation by flow and basal stimulation by nano-s
 cale substrate patterning. Finally\, I will discuss the role of proteins t
 hat link the cytoskeleton to the nucleus in modulating mechanotransduction
  in endothelial cells.
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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