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TZID:Europe/Paris
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BEGIN:VEVENT
UID:0-632@lptms.universite-paris-saclay.fr
DTSTART:20181205T110000Z
DTEND:20181205T120000Z
DTSTAMP:20181203T125711Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-ana-jesus-garcia-saez/
SUMMARY:Physics-Biology interface seminar: Ana-Jesus Garcia-Saez - Moyen Am
 phi\, Building 510\, Université Paris-Saclay Orsay - 5 Déc 18 11:00
DESCRIPTION:Single molecule analysis of mitochondrial permeabilization in a
 poptosis\nAna-Jesus Garcia-Saez (MPI Tübingen\, Germany)\nBax and Bak are
  key regulators of apoptosis and mediate the permeabilization of the outer
  mitocondrial membrane that leads to cytochrome and Smac release. Although
  it is widely accepted that Bax and Bak function and molecular mechanism l
 argely overlap\, there is limited evidence how Bak works. In previous stud
 ies\, we have used single molecule microscopy to characterize the oligomer
 ization of Bax in the membrane and its organization at the nanoscale in th
 e mitochondria of apoptotic cells. We now extended these approaches to Bak
  and identified key structural differences between the two proteins that m
 ay have functional implications.
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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