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TZID:Europe/Paris
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BEGIN:VEVENT
UID:0-658@lptms.universite-paris-saclay.fr
DTSTART:20190213T110000Z
DTEND:20190213T120000Z
DTSTAMP:20190203T212314Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-andela-saric/
SUMMARY:Physics-Biology interface seminar: Andela Saric - Moyen Amphi\, Bui
 lding 510\, Université Paris-Saclay Orsay - 13 Fév 19 11:00
DESCRIPTION:Sensing and creating mechanical forces by protein assembly\nAnd
 ela Saric (University College London\, UK)\nResponding to mechanical cues 
 and producing mechanical forces is central to survival and adaptation of a
 ll organisms. To do so\, cells dynamically organise a large number of memb
 rane proteins into functional nanoscale structures. Due to their multiscal
 e nature\, such processes are challenging to resolve with current experime
 ntal techniques and are too complex for detailed molecular simulations. Co
 arse-grained computer simulations\, rooted in statistical mechanics and so
 ft-matter physics\, can be of great value in determining how functional pr
 otein nanostructures operate. Here I will discuss cooperative gating of me
 chanosensitive membrane channels\, and the production of mechanical forces
  by elastic filaments adsorbed on membranes\, using minimal coarse-grained
  models. I will provide quantitative predictions for cooperative action of
  bacterial mechanosensitive channels\, from molecular to cellular scales. 
 I will propose how geometrical transitions of ESCRT-III filaments can remo
 del and sever membranes of various shapes and topologies\, creating membra
 ne cones\, tubes\, buds\, and dividing tubular and spherical membranes. Be
 yond their biological context\, our findings can also guide the design of 
 artificial structures that mechanically sculpt cells and sense mechanical 
 forces at the nanoscale.\n\n
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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