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TZID:Europe/Paris
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UID:1-126@lptms.universite-paris-saclay.fr
DTSTART:20130322T140000Z
DTEND:20130322T140000Z
DTSTAMP:20130418T124042Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-andrea-de-martino/
SUMMARY:Physics-Biology interface seminar : Andrea De Martino - Amphi BLAND
 IN du LPS de la Faculté des Sciences d’Orsay (Bâtiment 510) - 22 Mar 1
 3 14:00
DESCRIPTION:MicroRNAs: a selective channel of communication between competi
 ng RNAs\nAndrea De Martino (Sapienza Universita' di Roma)\nIt has recently
  been suggested that the competition for a finite pool of microRNAs (miRNA
 ) gives rise to effective interactions among their common targets (competi
 ng endogenous RNAs or ceRNAs) that could prove to be crucial for post-tran
 scriptional regulation (PTR). I shall discuss a minimal model of PTR where
  the emergence and the nature of such interactions can be characterized in
  detail at steady state. Sensitivity analysis shows that binding free ener
 gies and repression mechanisms are the key ingredients for the cross-talk 
 between ceRNAs to arise. Interactions emerge in specific ranges of repress
 ion values\, can be symmetrical (one ceRNA influences another and vice-ver
 sa) or asymmetrical (one ceRNA influences another but not the reverse) and
  may be highly selective\, while possibly limited by noise. Finally\, I wi
 ll show that non-trivial correlations among ceRNAs can emerge in experimen
 tal readouts due to transcriptional fluctuations even in absence of miRNA-
 mediated cross-talk\, so that more refined analyses will be needed to iden
 tify signatures of cross-talk in the transcriptome.
LOCATION:Amphi BLANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtim
 ent 510)\, 15 Rue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Amphi BLANDIN du LPS de la Facu
 lté des Sciences d’Orsay (Bâtiment 510):geo:48.698187,2.181768
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