BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//wp-events-plugin.com//6.4.7.2//EN
TZID:Europe/Paris
X-WR-TIMEZONE:Europe/Paris
BEGIN:VEVENT
UID:1-306@lptms.universite-paris-saclay.fr
DTSTART:20150209T110000Z
DTEND:20150209T120000Z
DTSTAMP:20150203T065957Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-andrew-callan-jones/
SUMMARY:Physics-Biology interface seminar: Andrew Callan-Jones - Moyen Amph
 i\, Building 510\, Université Paris-Saclay Orsay - 9 Fév 15 11:00
DESCRIPTION:The Cytoskeleton as an Active Gel: Modelling Cell Polarization\
 , Shape Change\, and Migration\nAndrew Callan-Jones (Université Paris-Did
 erot)\nCell polarization and shape change are required for large-scale mov
 ements during embryo development and cancer metastasis. I will present rec
 ent work to understand these phenomena by studying two model systems: zebr
 afish embryos during gastrulation and confined HeLa cells. In both cases\,
  individual cells are observed to undergo a novel type of polarization and
  transformation to a motile state that is crucially dependent on elevated 
 levels of contractility in the actomyosin cortex. Polarization of zebrafis
 h cells in vitro can be triggered by stimulating myosin activity: initiall
 y quasi-spherical\, immobile cells switch to a polarized state characteriz
 ed by a high cortical density at the cell rear\, persistent cortical actin
  flows\, and a distinctive pear-like morphology. Compressing HeLa cells be
 tween two plates results in a transition from a well-spread\, mesenchymal-
 type migration mode to a rounded-up one sustained by cortical flow\, and d
 isplaying an actin rich uropod at the rear\, reminiscent of zebrafish.\n\n
 We have modeled these cell mechanical responses using active gel theory\, 
 a continuum-level description of out-of-equilibrium behavior of the cytosk
 eleton. In this talk\, I will first provide a summary of this theory\, and
  will then show how it accounts for the principal features of contractilit
 y-based polarization: cortical flow and density changes\, cell shape chang
 e\, and migration.
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
END:VEVENT
END:VCALENDAR