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UID:0-1090@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20260403T110000
DTEND;TZID=Europe/Paris:20260403T120000
DTSTAMP:20260401T183556Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-anja-bockmann/
SUMMARY:Physics-Biology Interface seminar: Anja Böckmann - Moyen Amphi\, B
 uilding 510\, Université Paris-Saclay Orsay - 3 Avr 26 11:00
DESCRIPTION:Solid-state NMR of protein fibrils\nAnja Böckmann (Molecular M
 icrobiology and Structural Biochemistry Institute (MMSB) - CNRS/Lyon Unive
 rsity)\nSolid-state NMR was the first high-resolution structural biology a
 pproach to provide insights into the molecular organization of protein fib
 rils. Fibrils are best known for their role in neurodegenerative diseases 
 such as Alzheimer’s and Parkinson’s\, but they are actually far more w
 idespread and functionally diverse\, as they are also found in connection 
 with bacterial and viral infections\, among other things. A characteristic
  feature of many protein fibrils is that they violate the Anfinsen dogma\,
  according to which the native structure is determined exclusively by the 
 protein’s amino acid sequence. I will introduce the concepts of structur
 al biology\, solid-state NMR\, and the solid-state NMR linewidth\, which p
 rovides access to the diverse states in protein fibrils and serves as a me
 asure of the static and dynamic disorder exhibited by biological objects a
 t the atomic level. I will illustrate these concepts with examples of crys
 talline\, fibrillar\, and membrane-bound proteins.\n\nThe seminar will be 
 accessible remotely: https://rendez-vous.renater.fr/PhysBio_Seminar_April3
 _015e07-79620f-34760d\n
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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DTSTART:20260329T030000
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