BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//wp-events-plugin.com//6.4.7.2//EN
TZID:Europe/Paris
X-WR-TIMEZONE:Europe/Paris
BEGIN:VEVENT
UID:0-836@lptms.universite-paris-saclay.fr
DTSTART:20220930T110000Z
DTEND:20220930T120000Z
DTSTAMP:20220927T091115Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-anne-marie-haghiri/
SUMMARY:Physics-Biology interface seminar: Anne-Marie Haghiri - Moyen Amphi
 \, Building 510\, Université Paris-Saclay Orsay - 30 Sep 22 11:00
DESCRIPTION:Microfluidics and “Organs-on-chip”: is it possible to mimic
  blood vessels?\nAnne-Marie Haghiri (C2N)\n“Organs-on-a-chip” aim to c
 apture key functions that are indispensable for the physiological function
 ing of a specific organ by mimicking the tissue elements that perform thes
 e functions in vivo. In this context\, microfluidics offers the ability to
  reconstruct in vitro biological microenvironments with all the biophysica
 l and biochemical expected parameters including cellular coatings. Along t
 his talk\, I will focus on microfluidic devices aiming to mimic blood micr
 ovessels based on two complementary approaches.\n\nThe first approach conc
 erns the microfluidic wearable artificial lung that recovers on chip the p
 hysiological function of breath. A microfluidic oxygenator mainly consists
  of three layers with a thin gas permeable membrane sandwiched between a b
 lood microcapillaries network and a gas network. To meet clinical demands\
 , such device must therefore meet certain requirements\, which are 1/ supp
 ort high blood flow without reducing the gas transfer efficiency\, 2/ mini
 mize pressure drop and shear stress in the blood module\, 3/ enhance hemoc
 ompatibility by coatings. Our device has been designed at the 4-inch wafer
  scale with very dense curved blood and oxygen microcapillaries separated 
 by a 15 µm-thick porous membrane [1]. Such design allows reducing both pr
 iming volume while maintaining efficient gas exchange. Biomimetic blood fl
 ow paths with low shear rate also promotes sustainable endothelialization 
 since cells can be maintained viable for up to 2 weeks after initial seedi
 ng. The simplicity of connecting different units in the stacked architectu
 re has also been demonstrated for 3- or 5-unit stacked devices that exhibi
 t remarkable performance with low primary volume\, high oxygen uptake and 
 carbon dioxide release and high flow rate up to 80 ml/min [2].\n\nThe seco
 nd more conventional approach consists to generate microvasculature direct
 ly inside the chip where a tumor model is growing. Here\, we developed a s
 imple method to fabricate high aspect ratio 3D microfluidic devices\, as g
 eometrically optimized microenvironment for long-term culture and vascular
 ization of 3D tumor models (i.e.\, spheroids). The role of the height of t
 he central chamber on the growth of a heterotypic pancreatic tumor spheroi
 d\, made of cancer cells and fibroblasts is under study. We recently demon
 strated that a 500µm-thick microfluidic chamber promotes more gradual cel
 l growth and migration\, thanks to the availability of space for spheroid 
 evolution. Finally\, I will conclude on the importance of innovative desig
 n/architecture coupled with adapted microfabrication processes.\n\nReferen
 ces:\n[1] A-M. Haghiri-Gosnet\, Lyas Djeghlaf\, Julie Lachaux\, Alisier Pa
 ris\, Gilgueng Hwang\, European Patent EP18306405.4 (29 Oct. 2018) "Microf
 luidic gas exchange devices and methods for making same"\n[2] Julie Lachau
 x\, Gilgueng Hwang\, Nassim Arouche\, Sina Naserian\, Abdelmounaim Harouri
 \, V. Lotito\, C. Casari\, T. Lok\, J B. Menager\, J. Issard\, J. Guihaire
 \, C. V. Denis\, P. J. Lenting\, A. I. Barakat\, G. Uzan\, O. Mercier\, An
 ne Marie Haghiri-Gosnet\, Lab Chip\, 2021\, 21\, 4791 DOI:10.1039/d1lc0035
 6a\n\n&nbsp\;\n\nMerci de contacter eric.raspaud@universite-paris-saclay.f
 r et antoine.fruleux@universite-paris-saclay.fr si vous désirez rencontre
 r\nl’oratrice/l'orateur ou déjeuner avec nous.
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
END:VEVENT
END:VCALENDAR