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TZID:Europe/Paris
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UID:1-489@lptms.universite-paris-saclay.fr
DTSTART:20170125T110000Z
DTEND:20170125T120000Z
DTSTAMP:20170116T164021Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-antoine-jegou/
SUMMARY:Physics-Biology interface seminar: Antoine Jégou - LPTMS\, salle 2
 01\, 2ème étage\, Bât 100\, Campus d'Orsay - 25 Jan 17 11:00
DESCRIPTION:Building and disassembling actin filaments with proteins and fo
 rces\nAntoine Jégou (Institut Jacques Monod\, France)\n\nThe actin cytosk
 eleton comprises several networks essential for the cell to perform many k
 ey functions (motility\, cell division\, tissue cohesion\, …). Their ass
 embly and disassembly is tightly regulated\, in space and time\, by a myri
 ad of actin binding proteins but also by the mechanical stress applied to 
 those networks. We take advantage of a simple setup based on microfluidics
  and fluorescence microscopy\, to manipulate actin filaments in vitro and 
 assay the regulation of actin assembly. Focusing first on the assembly of 
 filaments by formins\, which are able to track filament barbed ends and ac
 celerate their elongation from profilin-actin\, we will show how tracking 
 and rapid elongation are modulated by filament tension and regulatory prot
 eins. We will then focus on ADF/cofilin isoforms\, which play a central in
  filament disassembly. We will show how ADF/cofilin fragments and depolyme
 rizes filaments through different mechanisms\, targeting both the side and
  the ends of the filaments.\n
CATEGORIES:physbio,seminars
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
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