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UID:0-1092@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20260109T110000
DTEND;TZID=Europe/Paris:20260109T120000
DTSTAMP:20260105T105836Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-arthur-molines/
SUMMARY:Physics-Biology interface seminar: Arthur Molines - Salle des sémi
 naires du FAST et du LPTMS\, bâtiment Pascal n°530 - 9 Jan 26 11:00
DESCRIPTION:Arthur Molines (I2BC Gif-sur-Yvette)\nEffect of viscosity and c
 rowding on cytoskeleton dynamics: an in vitro and in vivo exploration\nThe
  cytoplasm is a crowded\, viscoelastic environment whose physical properti
 es change according to physiological or developmental states. The physical
  properties of the cytoplasm\, which impact cellular functions in vivo\, r
 emain poorly understood. Here\, we probe the effects of cytoplasmic concen
 tration on microtubules by applying osmotic shifts to fission yeast\, moss
 \, and mammalian cells. We demonstrate that the rates of both microtubule 
 polymerization and depolymerization scale linearly and inversely with cyto
 plasmic concentration. An increase in cytoplasmic concentration proportion
 ally decreases the rates of microtubule polymerization and depolymerizatio
 n\, whereas a decrease in cytoplasmic concentration leads to the opposite 
 effect. Numerous lines of evidence indicate that these effects are due to 
 changes in cytoplasmic viscosity rather than cellular stress responses or 
 macromolecular crowding per se. We reconstituted these effects on microtub
 ules in vitro by tuning viscosity. Our findings indicate that\, even in no
 rmal conditions\, the viscosity of the cytoplasm modulates the reactions t
 hat underlie microtubule dynamic behaviors.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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