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BEGIN:VEVENT
UID:1-476@lptms.universite-paris-saclay.fr
DTSTART:20161214T110000Z
DTEND:20161214T120000Z
DTSTAMP:20161208T135708Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-atef-asnacios/
SUMMARY:Physics-Biology interface seminar: Atef Asnacios - LPTMS\, salle 20
 1\, 2ème étage\, Bât 100\, Campus d'Orsay - 14 Déc 16 11:00
DESCRIPTION:Mechanosensing: insights from experimental physics at the singl
 e-cell scale\nAtef Asnacios (MSC\, Université Paris-Diderot\, France)\nNO
 TE THE NEW LOCATION (due to renovation work at LPS)\nAs part of their phys
 iological functions\, most cells need to adapt to their mechanical environ
 ment. In particular\, the rigidity of the extracellular matrix was shown t
 o control cell traction forces\, shape\, and ultimately cell differentiati
 on. In this context\, most studies focused on the role of biochemical regu
 lation in rigidity sensing.\nIn contrast to this biochemical signaling-cen
 tered approach\, our aim is to reveal the physical/mechanical phenomena in
 volved in mechanosensing. To this end\, we have developed original single-
 cell techniques combining mechanical measurements (traction force\, mechan
 ical power…) with monitoring of cell structures (evanescent wave microsc
 opy). In particular\, we have designed a unique protocol allowing us to ch
 ange the effective stiffness felt by a single cell in real time (~0.1 seco
 nd)\, thus allowing us to show that an early purely mechanical response of
  single cell to stiffness indeed does exist.\nWe will present the results 
 of experiments combining single-cell traction force measurements\, dynamic
  control of stiffness\, and monitoring of adhesion complexes\, and will di
 scuss how cell shape (~ contact angle) and mechanical adaptation to rigidi
 ty (~ impedance matching) could control cell fate.\n
CATEGORIES:physbio,seminars
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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