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UID:0-916@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20240119T110000
DTEND;TZID=Europe/Paris:20240119T120000
DTSTAMP:20240116T200101Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-catherine-villard/
SUMMARY:Physics-Biology Interface seminar: Catherine Villard - Moyen Amphi\
 , Building 510\, Université Paris-Saclay Orsay - 19 Jan 24 11:00
DESCRIPTION:Fast deformation under flow and morphological recovery of cance
 r cells\nCatherine Villard (U. Paris-Cité)\nWarning: joint seminar with L
 PS\, takes place at LPS\n\nThe cancer metastatic cascade includes a blood 
 circulation step for cells detached from the primary tumor. This stage inv
 olves significant shear stress as well as large and fast deformations as t
 he cells circulate through the microvasculature. The recovery dynamics aft
 er deformation is pivotal to understand how a cell can pass through the mu
 ltiple capillary constrictions encountered during a single hemodynamic cyc
 le.   \n\nI will present results on the recovery dynamics of circulating c
 ells representative of different cancer phenotypes and their nuclei\, obta
 ined thanks to a dedicated microfluidic system we have recently developed.
 \n\nIn brief\, all cell types display an elastic recovery behavior followe
 d by a slower viscoelastic regime\, while nuclei\, depending on the cell t
 ype\, can strikingly recover purely elastically over a time scale of 20 ms
 . The fast elastic cell recovery regime is under the control of cell contr
 actility ensured by the integrity of the cell acto-myosin cortex while the
  presence of a vimentin cage around the nuclei  confers elastic properties
  to this organelle.\n\nI will finally discuss how these behaviors can poss
 ibly impact cell transit and survival into the blood circulation.
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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