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TZID:Europe/Paris
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UID:0-786@lptms.universite-paris-saclay.fr
DTSTART:20211013T110000Z
DTEND:20211013T120000Z
DTSTAMP:20211005T164704Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-cecile-leduc/
SUMMARY:Physics-Biology interface seminar: Cécile Leduc - Salle des sémin
 aires du FAST et du LPTMS\, bâtiment Pascal n°530 - 13 Oct 21 11:00
DESCRIPTION:Structure and assembly of single intermediate filaments\nCécil
 e Leduc (Institut Jacques Monod)\nIntermediate filaments (IF) are involved
  in key cellular functions including polarization\, migration\, and protec
 tion against large deformations. These functions are related to their rema
 rkable ability to extend without breaking\, a capacity that should be dete
 rmined by the molecular organization of subunits within filaments. However
 \, this structure-mechanics relationship remains poorly understood at the 
 molecular level. Here\, using super-resolution microscopy (SRM)\, we show 
 that vimentin filaments exhibit a ~49 nm axial repeat both in cells and in
  vitro. As unit-length-filaments (ULFs) precursors were measured at ~59 nm
 \, this demonstrates a partial overlap of ULFs during filament assembly. U
 sing an SRM-compatible stretching device\, we also provide evidence that t
 he extensibility of vimentin is due to the unfolding of its subunits and n
 ot to their sliding\, thus establishing a direct link between the structur
 al organization and its mechanical properties. Overall\, our results pave 
 the way for future studies of IF assembly\, mechanical and structural prop
 erties in cells.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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