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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-120@lptms.universite-paris-saclay.fr
DTSTART:20130405T140000Z
DTEND:20130405T140000Z
DTSTAMP:20130418T124006Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-chase-broedersz/
SUMMARY:Physics-Biology interface seminar : Chase Broedersz - Amphi BLANDIN
  du LPS de la Faculté des Sciences d’Orsay (Bâtiment 510) - 5 Avr 13 1
 4:00
DESCRIPTION:Localization and condensation of the parB-DNA complex in the ba
 cterial chromosome\nChase Broedersz (Princeton University)\nThe molecular 
 machinery responsible for faithful segregation of the chromosome in bacter
 ia such as Caulobacter crescentus and Bacillus subtilis includes the ParAB
 S a.k.a. Spo0J/Soj partitioning system. In Caulobacter\, prior to division
 \, hundreds of ParB proteins bind to the chromosome near the origin of rep
 lication\, and localize to one pole of the cell. Subsequently\, the ParB-D
 NA complex is translocated to the far pole by the binding and retraction o
 f the ParA spindle-like apparatus. Remarkably\, the localization of ParB p
 roteins to specific regions of the chromosome appears to be controlled by 
 only a few centromeric parS binding sites. Although lateral interactions b
 etween DNA-bound ParB are likely to be important for their localization\, 
 the long-range order of ParB domains on the chromosome appears to be incon
 sistent with a picture in which protein-protein interactions are limited t
 o neighboring DNA-bound proteins. We propose a simple model to study the l
 ocalization and condensation of the ParB-DNA complex\, which includes both
  lateral and 3D protein-protein interactions among DNA-bound ParB proteins
 . Our model shows how such interactions can condense and organize the chro
 mosome spatially\, and can control both the localization and the long-rang
 e order of the DNA-bound proteins. Interestingly\, the condensed ParB-DNA 
 complex adopts a topology in which loops of DNA extend outside the cluster
  exposed for transcription\; this structure may have implications for expr
 ession levels of genes in the vicinity of the parS site.
LOCATION:Amphi BLANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtim
 ent 510)\, 15 Rue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Amphi BLANDIN du LPS de la Facu
 lté des Sciences d’Orsay (Bâtiment 510):geo:48.698187,2.181768
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