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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-117@lptms.universite-paris-saclay.fr
DTSTART:20130531T140000Z
DTEND:20130531T140000Z
DTSTAMP:20130521T070226Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-claire-wilhelm/
SUMMARY:Physics-Biology interface seminar : Claire Wilhelm - Amphi BLANDIN 
 du LPS de la Faculté des Sciences d’Orsay (Bâtiment 510) - 31 Mai 13 1
 4:00
DESCRIPTION:Magnetic living cells: New tools for cell imaging\, tissue engi
 neering and cell therapies\nClaire Wilhelm (Université Paris 7)\nRecent a
 dvances in cell therapy and tissue engineering opened new windows for rege
 nerative medicine\, but still necessitate innovative techniques to create 
 and image functional tissues. One promising approach is to associate magne
 tic nanoparticles with cells in order to supply them with sufficient magne
 tization to be detectable by MRI or manipulated by magnetic forces\, while
  maintaining cell viability and functionalities. A few years ago\, we prop
 osed the use of anionic iron oxide nanoparticles as efficient agents for c
 ell internalisation without impacting cell functions. Recently we examined
  the influence of the amount of internalized iron and the state of nanopar
 ticle aggregation on the capacity for mesenchymal stem cell differentiatio
 n and MRI single cell tracking. We then demonstrated that high resolution 
 Magnetic Resonance Imaging (MRI) allowed combining cellular-scale resoluti
 on with the ability to detect two cell types simultaneously at any tissue 
 depth. In parallel\, we addressed the challenge to create a functional tis
 sue from stem cells in vitro. The aim was to confine stem cells in three d
 imensions at the millimetric scale by using home-designed miniaturized mag
 netic devices\, in order to create cellular patterns for stem cell differe
 ntiation and tissue engineering.\nFinally magnetic nanoparticles show also
  great promises for antitumor cell therapies\, in particular using the mag
 netic hyperthermia modality. Cellular internalization of magnetic nanopart
 icles localizes the source of heat in the internal volume of the cell\, wi
 th direct application for tumor cell therapies. The combination of cell-de
 rived vesicles with magnetic nanoparticles creates multifunctional bio-ins
 pired nanovectors with promising potential for diagnosis and therapy.
LOCATION:Amphi BLANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtim
 ent 510)\, 15 Rue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Amphi BLANDIN du LPS de la Facu
 lté des Sciences d’Orsay (Bâtiment 510):geo:48.698187,2.181768
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