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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-481@lptms.universite-paris-saclay.fr
DTSTART:20170308T110000Z
DTEND:20170308T120000Z
DTSTAMP:20170303T071123Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-daniel-jost/
SUMMARY:Physics-Biology interface seminar: Daniel Jost - LPTMS\, salle 201\
 , 2ème étage\, Bât 100\, Campus d'Orsay - 8 Mar 17 11:00
DESCRIPTION:Physical biology of chromatin: understanding the functional rol
 e of 3D chromosome folding using polymer physics\nDaniel Jost (Université
  Grenoble Alpes)\nCellular differentiation occurs during the development o
 f multicellular organisms and leads to the formation of many different tis
 sues where gene expression is modulated without modification of the geneti
 c information. These modulations are in part encoded by chromatin-associat
 ed proteins or biochemical tags that are set down at the chromatin level d
 irectly on DNA or on histone tails. These markers are directly or indirect
 ly involved in the local organization and structure of the chromatin fiber
 \, and therefore may modulate the accessibility of DNA to transcription fa
 ctors or enzymatic complexes\, playing a fundamental role in the transcrip
 tional regulation of gene expression.  Propagation\, maintenance and inher
 itance of these epigenetic marks are crucial mechanisms in development\, p
 henotype stabilization and disease. Experimental evidence have shown that 
 the pattern of chromatin markers along chromosomes is strongly correlated 
 with the 3D chromatin organization inside the nucleus. This suggests a cou
 pling between epigenomic information and large-scale chromatin structure. 
 Here\, I will discuss our recent works using polymer physics and numerical
  simulations trying to understand the basic principles behind such couplin
 g and and to propose possible functional roles for the 3D organization of 
 chromosomes.
CATEGORIES:physbio,seminars
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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