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TZID:Europe/Paris
X-WR-TIMEZONE:Europe/Paris
BEGIN:VEVENT
UID:0-667@lptms.universite-paris-saclay.fr
DTSTART:20190327T110000Z
DTEND:20190327T120000Z
DTSTAMP:20190314T063845Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-daria-bonazzi/
SUMMARY:Physics-Biology interface seminar: Daria Bonazzi - Moyen Amphi\, Bu
 ilding 510\, Université Paris-Saclay Orsay - 27 Mar 19 11:00
DESCRIPTION:Bacterial aggregates of Neisseria meningitidis flow inside bloo
 d vessels like a honey-like viscous liquid\nDaria Bonazzi (Institut Pasteu
 r\, Paris)\nDuring human meningococcal infections\, bacteria accumulate an
 d finally fill up blood vessels\, causing severe diseases such as septicae
 mia and meningitis. However\, the mechanisms governing formation of bacter
 ial aggregates and their impact on infection remained elusive. In this mul
 tidisciplinary work we unravel that aggregates of Neisseria meningitidis b
 ehave as a viscous liquid similar to honey. This is due to type-IV pili\, 
 long adhesive filaments which are constantly extending and retracting at t
 he bacterial surface. By these means\, bacteria can find each other and tr
 ansiently come into contact. Aggregation is therefore based on an intermit
 tent process of attraction between bacteria\, and gives rise to a new type
  of active material. Importantly\, the unique physical properties of menin
 gococcal aggregates allow them to gradually adapt to the complex geometry 
 of the vascular network. As a consequence\, these physical properties are 
 essential for the progression of infection.
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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