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TZID:Europe/Paris
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BEGIN:VEVENT
UID:0-803@lptms.universite-paris-saclay.fr
DTSTART:20220525T110000Z
DTEND:20220525T120000Z
DTSTAMP:20220511T094412Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-davide-michieletto/
SUMMARY:Physics-Biology interface seminar: Davide Michieletto - Salle des s
 éminaires du FAST et du LPTMS\, bâtiment Pascal n°530 - 25 Mai 22 11:00
DESCRIPTION:Topologically Active Polymers\nDavide Michieletto (University o
 f Edinburgh)\nPolymer physics successfully describes most of the polymeri
 c materials that we encounter everyday. In spite of this\, it heavily re
 lies on the assumption that polymers do not change topology (or architect
 ure) in time or that\, if they do alter their morphology\, they do so in e
 quilibrium. This assumption spectacularly fails for DNA in vivo\, which is
  constantly topologically re-arranged by ATP-consuming proteins within th
 e cell nucleus.\nInspired by this\, here I will discuss some non-equilibr
 ium complex fluids in which DNA topology is selectively altered in time by
  proteins. I argue that solutions of "topologically active” polymers ca
 n display unconventional viscoelastic behaviours and can be conveniently 
 realised using solutions of DNA functionalised by certain families of vit
 ally important proteins.\nMore specifically\, in this talk I will present
  some results using both theory/simulations and experiments on the microrh
 eology of entangled DNA undergoing digestion by restriction enzymes and l
 igation by ligase. I will try to convince you that that we can harness the
 se topological processes to design complex fluids with exotic and time-var
 ying viscoelastic behaviours.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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