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TZID:Europe/Paris
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BEGIN:VEVENT
UID:0-720@lptms.universite-paris-saclay.fr
DTSTART:20200311T110000Z
DTEND:20200311T120000Z
DTSTAMP:20200304T151459Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-davy-martin/
SUMMARY:Physics-Biology interface seminar: Davy Martin - Salle des séminai
 res du FAST et du LPTMS\, bâtiment Pascal n°530 - 11 Mar 20 11:00
DESCRIPTION:Prion replication and structural diversification mechanisms\nDa
 vy Martin (INRA Jouy-en-Josas)\nPrions are proteinaceous infectious agents
  responsible for a range of neurodegenerative diseases in animals and huma
 ns. Prion particles are assemblies formed from a misfolded\, β-sheet rich
 \, aggregation-prone isoform (PrPSc) of the host-encoded cellular prion pr
 otein (PrPC). Prions replicate by recruiting and converting PrPC into PrPS
 c. PrPSc is a pleiomorphic protein as different conformations can dictate 
 different disease phenotypes in the same host species. This is the basis o
 f the strain phenomenon in prion diseases. Moreover\, recent experimental 
 evidence suggests further structural heterogeneity in PrPSc assemblies wit
 hin specific prion populations and strains. Still\, this diversity is rath
 er seen as a size continuum of assemblies with the same core structure\, w
 hile analysis of the available experimental data points to the existence o
 f structurally distinct arrangements. The atomic structure of PrPSc has no
 t been elucidated so far\, making the underlying mechanistical processes o
 f emergence and coevolution of structurally distinct assemblies difficult 
 to understood. Here\, we will present our latest experimental results and 
 replication model providing mechanistic insights into prion structural div
 ersification\, a key determinant for prion adaptation and toxicity.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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