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UID:0-1059@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20251017T110000
DTEND;TZID=Europe/Paris:20251017T120000
DTSTAMP:20251006T215337Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-dennis-worthmuller/
SUMMARY:Physics-Biology Interface seminar: Dennis Wörthmüller - Salle des
  séminaires du FAST et du LPTMS\, bâtiment Pascal n°530 - 17 Oct 25 11:
 00
DESCRIPTION:When Actin Meets Curvature: Modeling Free-Standing Cell Protrus
 ions\nDennis Wörthmüller (Institut Curie)\nCell shape changes are largel
 y controlled by the actin cytoskeleton\, a dynamic filament network beneat
 h the plasma membrane. Some cell types can form extended free-standing pro
 trusions that are not supported by an extracellular substrate\, and whose 
 initiation is thought to rely on proteins that modulate actin dynamics thr
 ough sensitivity to membrane curvature. I will present a theoretical model
  for a free-standing viscous actin network growing on a corrugated membran
 e\, which couples active-gel mechanics\, membrane deformation\, and the re
 cruitment of curvature-sensitive actin nucleators. The model shows that un
 iform actin polymerization stabilizes membrane shape\, whereas curvature-d
 ependent nucleation can render the membrane linearly unstable and drive sp
 ontaneous deformations with a well-defined wavelength that could initiate 
 protrusions. To explore these processes beyond the linear regime\, we deve
 lop a finite-element framework that captures nonlinear deformations of flu
 id and elastic layers\, opening the way to realistic simulations of actin-
 driven membrane shape changes.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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DTSTART:20250330T030000
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