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TZID:Europe/Paris
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UID:0-862@lptms.universite-paris-saclay.fr
DTSTART:20221209T110000Z
DTEND:20221209T120000Z
DTSTAMP:20221209T082509Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-doron-grossman/
SUMMARY:Physics-Biology interface seminar: Doron Grossman - Moyen Amphi\, B
 uilding 510\, Université Paris-Saclay Orsay - 9 Déc 22 11:00
DESCRIPTION:Instabilities and Geometry of Growing Tissues\nDoron Grossman (
 College de France - for this work\; LadHyX\, Ecole polytechnique - current
 )\n\nWe present a covariant continuum formulation of a generalized two-dim
 ensional vertexlike model\nof epithelial tissues which describes tissues w
 ith different underlying geometries\, and allows for an\nanalytical macros
 copic description. Using a geometrical approach and out-of-equilibrium\nst
 atistical mechanics\, we calculate both mechanical and dynamical instabili
 ties of a tissue\, and\ntheir dependences on various variables\, including
  activity\, and cell-shape heterogeneity (disorder).\nWe show how both pla
 stic cellular rearrangements and the tissue elastic response depend on the
 \nexistence of mechanical residual stresses at the cellular level. Even fr
 eely growing tissues may\nexhibit a growth instability depending on the in
 trinsic proliferation rate. Our main result is an\nexplicit calculation of
  the cell pressure in a homeostatic state of a confined growing tissue. We
 \nshow that the homeostatic pressure can be negative and depends on the ex
 istence of mechanical\nresidual stresses. This geometric model allows us t
 o sort out elastic and plastic effects in a growing\,\nflowing\, tissue.\n
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
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