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TZID:Europe/Paris
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UID:0-826@lptms.universite-paris-saclay.fr
DTSTART:20220622T110000Z
DTEND:20220622T120000Z
DTSTAMP:20220615T072743Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-emmanuel-levy/
SUMMARY:Physics-Biology interface seminar: Emmanuel Levy - Salle des sémin
 aires du FAST et du LPTMS\, bâtiment Pascal n°530 - 22 Juin 22 11:00
DESCRIPTION:Principles of Protein Assembly\, From Molecules to Cells\nEmman
 uel Levy (Weizmann Institute of Science\, Israel)\nLife processes involve 
 an intricate choreography between tens of millions of protein building blo
 cks that form the infrastructure of cells. Recent technological advances h
 ave revealed the catalogs of proteins present in various cells and organis
 ms. However\, understanding how these protein building-blocks assemble and
  work together is an extraordinarily complex task. I will present our work
  aimed at addressing this challenge. First\, I will describe how stickines
 s\, defined as the chemical propensity of protein surfaces to bind to each
  other\, is tuned across entire proteomes to minimize promiscuous interact
 ions. Second\, I will show that even single point-mutations changing the s
 urface stickiness of homo-oligomeric proteins can trigger their infinite f
 olded-state self-assembly. Finally\, I will describe the design of synthet
 ic protein condensates with tractable and tunable phase behavior\; and wor
 k-in-progress\, on how we are using these condensates to identify genes gl
 obally regulating macromolecular self-assembly in cells.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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