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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-255@lptms.universite-paris-saclay.fr
DTSTART:20140620T140000Z
DTEND:20140620T150000Z
DTSTAMP:20140612T103321Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-francesco-piazza/
SUMMARY:Physics-Biology interface seminar: Francesco Piazza - Amphi BLANDIN
  du LPS de la Faculté des Sciences d’Orsay (Bâtiment 510) - 20 Juin 14
  14:00
DESCRIPTION:Diffusion-controlled reactions in complex media\nFrancesco Piaz
 za (Université d'Orléans)\nIn all biochemical reactions occurring in liv
 ing tissues\, reactants have to form an encounter complex before the speci
 fic chemical step. Invariably\, in order to reach their binding partners\,
  biomolecules have to diffuse in complex environments\, both very crowded 
 with all sorts of other biomolecules and organelles and confining\, due to
  the presence of different membranes and cytoskeletal structures that stro
 ngly compartimentalize the available space.\nUnder such conditions\, the s
 tandard Smoluchowski theory for biomolecular encounters valid in ideal sol
 utions is no longer applicable and the need emerges for more sophisticated
  theoretical paradigms accounting explcitly for crowding and confinement i
 n the computation of encounter rates.\nIn this talk\, I will illustrate a 
 general theoretical paradigm that we are developing in our group to solve 
 this problem. Using addition theorems for spherical harmonics\, we compute
  the diffusion rate to a sink in the presence of crowding agents that we m
 odel as spheres of arbitrary radius and endowed with arbitrary reactivity\
 , from fully reflecting (purely excluded volume) to fully absorbing (compe
 titive binding partners). We consider both diffusion in an unbounbded doma
 in and diffusion occurring within a spherical domain\, as an attempt to mo
 del encounters occurring within a cell. Different applications will be dis
 cussed\, such as diffusion to a binding pocket in a coarse-grained model o
 f protein and reactions occurring in vesicles and other kinds of nanoreact
 ors.
LOCATION:Amphi BLANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtim
 ent 510)\, 15 Rue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Amphi BLANDIN du LPS de la Facu
 lté des Sciences d’Orsay (Bâtiment 510):geo:48.698187,2.181768
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