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TZID:Europe/Paris
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UID:0-905@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20240202T110000
DTEND;TZID=Europe/Paris:20240202T120000
DTSTAMP:20240118T101330Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-francois-nedelec-2/
SUMMARY:Physics-Biology Interface Seminar: François Nédélec - Amphi de l
 'Institut Curie\, bâtiment 111 - 2 Fév 24 11:00
DESCRIPTION:Simple Chromosome Partitioning Mechanisms and Dynamics of a Mit
 otic Spindle.\n(Beware of the unusual location)\nFrançois Nédélec (Camb
 ridge University)\nWe are using theory to explore simple mechanisms of chr
 omosome partitioning with the aim of understanding the design principles o
 f mitotic spindle assembly. Firstly\, I will present how artificial evolut
 ion in a computer can uncover simple combinations of cytoskeletal elements
  that will self-organize to pull on a kinetochore pair symmetrically and r
 eliably. I will then discuss the requirements to extend such elementary me
 chanisms to build a mitotic spindle that can handle multiple chromosomes. 
 Secondly\, I will present the characteristics of the mitotic spindles foun
 d in the roots of Arabidopsis thaliana\, and argue that given these quanti
 ties\, this plant spindle stands out as an ideal subject to build a quanti
 tatively accurate 3D simulation. I will present our attempts to build such
  a model\, detailing some key assumptions and using a simulation to illust
 rate the remarkable dynamics of a metaphase mitotic spindle.
CATEGORIES:physbio,seminars
LOCATION:Amphi de l'Institut Curie\, bâtiment 111\, 111\, Rue Jean-Dominiq
 ue Cassini\, Bures-sur-Yvette\, 91440\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=111\, Rue Jean-Dominique Ca
 ssini\, Bures-sur-Yvette\, 91440\, France;X-APPLE-RADIUS=100;X-TITLE=Amphi
  de l'Institut Curie\, bâtiment 111:geo:0,0
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DTSTART:20231029T020000
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