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TZID:Europe/Paris
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UID:1-171@lptms.universite-paris-saclay.fr
DTSTART:20131206T110000Z
DTEND:20131206T120000Z
DTSTAMP:20131114T104956Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-francois-nedelec/
SUMMARY:Physics-Biology interface seminar: François Nédélec - Laboratoir
 e d'enzymologie et biochimie structurales - 6 Déc 13 11:00
DESCRIPTION:Optimal Design of Elongating Yeast Spindles\nFrançois Nédéle
 c (EMBL Heidelberg)\nJoint seminar with LEBS Gif-sur-Yvette\nSPECIAL TIME 
 AND LOCATION\nBundles of filaments are universal elements that belong to t
 he intracellular skeleton of eukaryotic cells. The anaphase spindle from f
 ission yeast is an excellent example of such bundle that assembles repeate
 dly in the same manner at every cell division. It is also an excellent exp
 erimental system since yeast cells can easily be perturbed genetically\, a
 nd their spindle is visualized using electron or light microscopy. The spi
 ndle is under compression at anaphase and based on electron tomographic re
 constructions of its constituent microtubules\, we calculated that the len
 gth and organization of microtubules within the fission yeast spindle are 
 optimized to achieve maximal strength while minimizing the use of material
 . A combination of simulations and live cell imaging further indicated whi
 ch of the properties of the microtubule cross-linkers are likely to be res
 ponsible for such a precise regulation of spindle morphology\, and the syn
 ergy that exists between the cross-linkers in fission yeast.\n
LOCATION:Laboratoire d'enzymologie et biochimie structurales\,  Bâtiment 3
 4 - Avenue de la Terrasse\, Gif-sur-Yvette\, 91190\, France
GEO:48.704609;2.132356
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 boratoire d'enzymologie et biochimie structurales:geo:48.704609,2.132356
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