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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-410@lptms.universite-paris-saclay.fr
DTSTART:20160307T110000Z
DTEND:20160307T120000Z
DTSTAMP:20160219T145015Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-frederic-pain/
SUMMARY:Physics-Biology interface seminar: Frédéric Pain - Petit Amphi\, 
 Building 510\, Université Paris-Sud Orsay - 7 Mar 16 11:00
DESCRIPTION:Assessment of optimal parameters for deep optogenetic stimulati
 ons in non human primate\nFrédéric Pain (IMNC\, Université Paris-Sud)\n
 SPECIAL LOCATION (next door from the usual one)\nOptogenetics has become u
 biquitous in fundamental neuroscience labs as a very powerful tool to unra
 vel brain networks connectivity and cellular mechanisms. Yet\, its clinica
 l translation requires a careful assessment of the inocuity of repeated an
 d sustained high power light stimulations. In a preliminary studies to tra
 nslational research in the field deep brain stimulation for Parkinson's di
 sease we have studied in vivo in anesthetized rats the potential damages a
 nd non-physiological effects produced by high power optical neurostimulati
 on in typical optogenetics experiments.2D Maps of light distribution and t
 emperature increase were recorded in wild type anesthetized rats brains fo
 r relevant optical stimulation protocols used in optogenetics. The spatial
  profile of light distribution and heat were correlated and demonstrated a
 s expected a rapid attenuation with distance to the fiber. Temperature inc
 rease remains below physiological changes for stimulations up to 400mW/mm
 ². \nI will present optogenetics issues in a clinical translational conte
 xt.
CATEGORIES:physbio,seminars
LOCATION:Petit Amphi\, Building 510\, Université Paris-Sud Orsay\, 15 Rue 
 Georges Clemenceau\, orsay\, France
GEO:48.699116;2.179468
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Petit Amphi\, Building 510\, Un
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