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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-296@lptms.universite-paris-saclay.fr
DTSTART:20141215T110000Z
DTEND:20141215T120000Z
DTSTAMP:20141208T094731Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-gilles-charvin/
SUMMARY:Physics-Biology interface seminar: Gilles Charvin - Moyen Amphi\, B
 uilding 510\, Université Paris-Saclay Orsay - 15 Déc 14 11:00
DESCRIPTION:Single cell analysis of entry into replicative senescence in bu
 dding yeast\nGilles Charvin (IGBMC Strasbourg)\nBudding yeast cells have a
 n asymmetrical division pattern. Each mother cell produces a limited numbe
 r of smaller daughter cells before entering senescence and eventually dyin
 g. The detailed mechanisms that govern entry into senescence in mothers an
 d daughter cell rejuvenation are still poorly understood. In this context\
 , we have developed a microfluidic system that lets one monitor the succes
 sive divisions of single yeast cells in real-time under the microscope. Us
 ing this device\, we have revisited classical paradigms associated with th
 e age-dependent control of cell proliferation in this unicellular organism
 . Our results indicate that cells undergo a sharp transition to senescence
 \, which is not related to the the loss of mitochondrial membrane potentia
 l\, as previously proposed. Other applications of our methodology to the s
 tudy of senescence induced by telomeres attrition and in other cellular bi
 ology contexts will be presented during the talk.
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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