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TZID:Europe/Paris
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UID:1-300@lptms.universite-paris-saclay.fr
DTSTART:20141103T110000Z
DTEND:20141103T120000Z
DTSTAMP:20141021T140320Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-guillaume-tresset/
SUMMARY:Physics-Biology interface seminar: Guillaume Tresset - Moyen Amphi\
 , Building 510\, Université Paris-Saclay Orsay - 3 Nov 14 11:00
DESCRIPTION:Understanding the self-assembly of simple icosahedral viruses\n
 Guillaume Tresset (Université Paris-Sud)\nViruses are ubiquitous pathogen
 s in all kingdoms of life and are major public health issues as well as ec
 onomic and veterinary concerns worldwide. Despite a huge body of work dedi
 cated to the molecular biology of viral life cycles\, there are currently 
 no physical models accounting reliably for the mechanisms by which the hun
 dreds of molecular building blocks making up a virus fit into the final st
 ructure with a pinpoint accuracy. I will first present the self-assembly p
 athway of empty icosahedral capsids derived from a bovine virus. A kinetic
  model constructed from time-resolved X-ray scattering data reveals a coop
 erative mechanism involving an unexpected long-lived intermediate species.
  Then\, I will give some insights into the packaging of polyelectrolytes b
 y capsid proteins derived from a plant virus. Accurate measurements of the
  mass of packaged polyelectrolyte demonstrate a nonspecific selectivity th
 at may play a crucial role for genome packaging in host cells. Quite gener
 ally\, physics provides a useful framework to describe viral self-assembly
  and should eventually support the development of novel therapeutic strate
 gies.
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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