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TZID:Europe/Paris
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UID:1-287@lptms.universite-paris-saclay.fr
DTSTART:20141001T140000Z
DTEND:20141001T150000Z
DTSTAMP:20140930T074633Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-huan-cheng-chang/
SUMMARY:Physics-Biology interface seminar: Huan-Cheng Chang - Moyen Amphi\,
  Building 510\, Université Paris-Saclay Orsay - 1 Oct 14 14:00
DESCRIPTION:Bioimaging and quantum sensing with ion-irradiated nanodiamonds
 \nHuan-Cheng Chang (Academia Sinica\, Taiwan)\nSeminar co-hosted by Franç
 ois Treussart\nSPECIAL TIME AND LOCATION\nAs a wide band-gap material\, di
 amond can contain a variety of atomic defects or impurities as color cente
 rs. Some of the color centers are highly luminescent\, while others are lu
 minescent with a very low quantum yield. For nanoscale diamonds (NDs) cont
 aining a high-density ensemble of vacancy-related defect centers\, they ar
 e useful as nanoprobes for bioimaging and quantum sensing both in vitro an
 d in vivo. In this seminar\, we will show how ion-irradiated NDs can be ro
 utinely produced in our laboratory. Three examples of the applications by 
 utilizing nitrogen-vacancy (NV−) centers and neutral vacancy (V0 or GR1)
  centers in NDs are discussed. First\, we will present our results of usin
 g fluorescence lifetime imaging microscopy to achieve background-free real
 -time imaging of fluorescent NDs (denoted as FNDs) in living organisms suc
 h as C. elegans. With 100-nm FNDs conjugated with yolk lipoprotein complex
 es\, we demonstrate that the nanoparticles serve well as a biomolecular na
 nocarrier without significantly altering the functionality of the cargos f
 or intercellular transport\, cell-specific targeting\, and long-term imagi
 ng applications in vivo. Second\, we report our recent work on the develop
 ment of highly ion-irradiated NDs (denoted as INDs) as a photoacoustic con
 trast agent for deep-tissue imaging. The particles are so extensively dama
 ged that graphitization occurs concurrently with the generation of the GR1
  centers. Although the IND of ~40 nm in diameter has a much smaller absorp
 tion coefficient than gold nanorods (GNRs) of similar dimensions at 1064 n
 m\, it shows a better performance due to higher thermal stability and a lo
 wer nanobubble formation threshold of the carbon-based nanomaterial. Final
 ly\, we apply the NV− centers in 100-nm FNDs for nanoscale temperature s
 ensing by optically detected magnetic resonance. We conjugate FNDs with GN
 Rs and employ them as both a nanoheater and a nanothermometer in solution 
 and cells. The integration of heating and temperature sensing functions on
  the same particles opens an opportunity for active and high-precision con
 trol of temperature at the nanoscale by pure optical means.
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
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