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UID:0-910@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20231013T110000
DTEND;TZID=Europe/Paris:20231013T120000
DTSTAMP:20230921T170201Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-iva-ganeva/
SUMMARY:Physics-Biology interface seminar: Iva Ganeva - Salle des séminair
 es du FAST et du LPTMS\, bâtiment Pascal n°530 - 13 Oct 23 11:00
DESCRIPTION:The architecture and mechanism of lipid transfer at interfaces 
 between lipid droplets\nIva Ganeva (University of Bern\, Switzerland)\n\nL
 ipid droplets (LDs) are intracellular organelles responsible for regulated
  storage and release of neutral lipids. LDs feature a neutral lipid core e
 nclosed by a phospholipid monolayer and surface proteins involved in lipid
  metabolism. The protein Cidec is crucial for LD enlargement and accumulat
 es at interfaces between LDs where it facilitates directional neutral lipi
 d transfer from the smaller to the larger LD. Deciphering the structure of
  the LD-LD interface is key in understanding the molecular mechanism of li
 pid transfer. We use live cell imaging and electron cryo-tomography of hum
 an cells to visualize interfaces between LDs and understand the mechanism 
 of lipid transfer directly inside cells. Furthermore\, by biochemical reco
 nstitutions using recombinant Cidec and various artificial membrane system
 s\, we aim at uncovering the minimal machinery for interface architecture 
 and lipid transfer function. Our current model is that lipid transfer occu
 rs through largely intact monolayers at an interface which resembles an or
 ganelle contact site. We hypothesise that this process is facilitated by t
 he ability of Cidec to induce lipid packing defects into the monolayers\, 
 thereby making them permeable for neutral lipids.   \n
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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