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UID:1-491@lptms.universite-paris-saclay.fr
DTSTART:20170614T110000Z
DTEND:20170614T120000Z
DTSTAMP:20170607T101830Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-ivo-sbalzarini/
SUMMARY:Physics-Biology interface seminar: Ivo Sbalzarini - LPTMS\, salle 2
 01\, 2ème étage\, Bât 100\, Campus d'Orsay - 14 Juin 17 11:00
DESCRIPTION:Investigating embryogenesis using numerical simulations of biop
 hysics\nIvo Sbalzarini (Max Planck Institute of Molecular Cell Biology and
  Genetics\, Dresden\, Germany)\n\nAbstract:\n\nDevelopment and morphogenes
 is of tissues\, organs\, and embryos emerges from the collective self-orga
 nization of cells that communicate though chemical and mechanical signals.
  Decisions about growth\, division\, and migration are taken locally by ea
 ch cell based on the collective information. In this sense\, a developing 
 tissue is akin to a massively parallel computer system\, where each cell o
 r processor computes robust local decisions\, integrating communication wi
 th other cells/processors. Mechanistically understanding and reprogramming
  this system is a grand challenge. Our vision is to develop a virtual comp
 uter model of a developing embryo\, incorporating the known biochemistry a
 nd biophysics into a computational model in 3D-space and time\, in order t
 o understand the information-processing aspects of development on an algor
 ithmic basis. While the “hardware” (proteins\, lipids\, etc.) and the 
 “source code” (genome) are increasingly known\, we known virtually not
 hing about the algorithms that this code implements on this hardware. Usin
 g examples from our work\, I outline our roadmap toward a virtual embryo\,
  and highlight challenges along the way. These range from globally optimal
  approaches to image analysis\, to novel languages for parallel high-perfo
 rmance computing\, to virtual reality and real-time graphics for 3D micros
 copy and numerical simulations of biochemical and biomechanical models. Th
 is cooperative interdisciplinary effort contributes to all involved discip
 lines.\n\n\nBio:\n\nIvo Sbalzarini is the Chair of Scientific Computing fo
 r Systems Biology on the faculty of computer science of TU Dresden\, and d
 irector of the TUD-Department in the Center for Systems Biology Dresden. H
 e also is a permanent Senior Research Group Leader with the Max Planck Ins
 titute of Molecular Cell Biology and Genetics in Dresden. He graduated in 
 Mechanical Engineering from ETH Zurich in 2002 (Willi Studer Award). He co
 mpleted his doctorate in computer science in 2006 at ETH Zurich (Chorafas 
 Award\, Weizmann Institute of Science)\, where he formed a close collabora
 tion between biology and computer science. In 2006\, he was named Assistan
 t Professor for Computational Science in the Department of Computer Scienc
 e of ETH Zurich. In 2012\, Ivo and his group moved to Dresden\, where he b
 ecame one of the founding members of the new Max Planck Center for Systems
  Biology and the TU-Dresden Chair of Scientific Computing for Systems Biol
 ogy. He also serves as a co-leader of the biological systems path of the C
 enter for Advancing Electronics Dresden\, Dean of the International Max Pl
 anck Research School in Cell\, Developmental\, and Systems Biology\, and V
 ice-Dean of the Faculty of Computer Science.\n
CATEGORIES:physbio,seminars
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
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