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UID:0-957@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20240524T110000
DTEND;TZID=Europe/Paris:20240524T120000
DTSTAMP:20240514T091708Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-jasper-van-der-gucht/
SUMMARY:Physics-Biology Interface Seminar: Jasper van der Gucht - Salle des
  séminaires du FAST et du LPTMS\, bâtiment Pascal n°530 - 24 Mai 24 11:
 00
DESCRIPTION:Catching up: towards bio-inspired catch-bonded materials \nJasp
 er van der Gucht (Wageningen U.\, the Netherlands)\n\nMany biological mate
 rials face conflicting mechanical demands: they must be dynamic and adapta
 ble on the one hand\, and robust and resilient on the other. Dynamicity as
 ks for labile bonds that readily dissociate and reform\, while resilience 
 asks for strong and long-lived bonds. Nature has found a solution for thes
 e seemingly contrasting requirements: catch bonds. While conventional bond
 s weaken under tension\, catch bonds do the opposite: they strengthen unde
 r stress. Under quiescent conditions the bonds are weak\, allowing for the
  dynamic rearrangements necessary for cell functioning\, but under conditi
 ons of high stress they stabilize\, thereby protecting the cells against m
 echanical stress. Since their discovery two decades ago\, catch bonds are 
 now recognized as a crucial design element for controlling cellular mechan
 ics. Yet\, how catch bonds exactly perform their task at the scale of netw
 orks and cells is not well understood. \n\n\nIn this presentation\, I will
  discuss two recent approaches from our group that aim to shed insight on 
 this. In the first part\, I will discuss simulation results of catch-bonde
 d polymer networks that show how catch bonds collectively protect networks
  against mechanical damage\, and in particular how the mobility of the bon
 ds influences this. In the second part\, I will share our efforts to desig
 n a synthetic DNA-based catch bond\, by using a combination of computation
 al design\, experiments and simulations. \n\n\nJ. Ruiz-Franco\,  J. Tauber
  & J. van der Gucht\, “Cross-linker Mobility Governs Fracture Behavior o
 f Catch-Bonded Networks”\, Physical Review Letters 130 (118203)\, 2023.\
 nM. van Galen\, A. Bok\, T. Peshkovsky\, J. van der Gucht\, B. Albada & J.
  Sprakel\, “De novo DNA-based catch bonds”\, Nature Chemistry\, in pre
 ss\, 2024.\n\n
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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