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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-371@lptms.universite-paris-saclay.fr
DTSTART:20151116T110000Z
DTEND:20151116T120000Z
DTSTAMP:20151030T073401Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-jens-elgeti/
SUMMARY:Physics-Biology interface seminar: Jens Elgeti - Moyen Amphi\, Buil
 ding 510\, Université Paris-Saclay Orsay - 16 Nov 15 11:00
DESCRIPTION:Simulating Growing Tissues\nJens Elgeti (Forschungszentrum Jül
 ich)\nGrowth of solid tumors or metastasis requires\, besides massive biom
 edical changes\, also a spatial remodelling of the tissue. This remodellin
 g\, often including displacements of healthy tissue around\, requires mech
 anical work to be done. These mechanics of growth has attracted a lot of a
 ttention in recent years\, but still remains poorly understood.\n\nWe use 
 particle based simulations to study mechanical properties and effects in g
 rowing and motile tissues. These simulations have been helpful in understa
 nding\, interpreting and designing experiments.  I will present an overvie
 w of the simulation technique\, and how it contributed to recent developme
 nts in three dimensional tissue growth and collective cell migration. In a
  recent series of simulations and close experimental collaborations we fou
 nd important interfacial and surface effects that lead to novel phenomena.
  For example\, the tissue divides favorably at a free surface\, even witho
 ut any nutrient effects. This leads to the possibility and stability of a 
 negative homeostatic pressure. In turn\, a negative homeostatic pressure l
 eads to naturally to finite steady states and tensile states.\n\nReference
 s:\n[1] M.Basan et al\, PNAS 110:2452 (2013)\n[2] F. Montel et al\, N. J. 
 Phys. 14:055008 (2012) \n[3] F. Montel  et al\, Phys. Rev. Lett. 107:18810
 2\, (2011)\n[4] M. Basan et al\, Phys. Biol. 8:026014\, (2011)\n[5] J. Ran
 ft et al\, PNAS 107:20863\, (2010)
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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