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UID:0-875@lptms.universite-paris-saclay.fr
DTSTART:20230421T110000Z
DTEND:20230421T121500Z
DTSTAMP:20230504T111757Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-romain-levayer/
SUMMARY:Physics-Biology interface seminar: Romain Levayer - Moyen Amphi\, B
 uilding 510\, Université Paris-Saclay Orsay - 21 Avr 23 11:00
DESCRIPTION:Collective effects in epithelial cell elimination\nRomain Levay
 er\, Department of Developmental and Stem Cell Biology\, Institut Pasteur\
 , Paris\, France\nWhile the signals regulating apoptosis during developmen
 t are rather well known\, what sets the precise spatio-temporal distributi
 on of cell death and the adjustment of cell elimination to local perturbat
 ions is not well understood. Similarly\, how cells eventually engage in ap
 optosis and how the removal of cells from epithelial layer is orchestrated
  through cell extrusion remained poorly understood\, especially in vivo. I
 n this seminar\, I will illustrate the multi-layered regulation of cell de
 ath through three examples\, the first one describing the impact of mechan
 ical stress on cell elimination\, the second one on local feedbacks that c
 an fine tune the distribution of cell elimination in space and time reveal
 ing interesting self-organising properties\, and the last one focusing on 
 the engagement in apoptosis and the coordination of cell extrusion by casp
 ases. Altogether\, I will propose a roadmap to build a more predictive und
 erstanding of cell death in vivo that can directly impact tissue homeostas
 is\, morphogenesis\, growth and clonal selection.
CATEGORIES:seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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