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TZID:Europe/Paris
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UID:0-837@lptms.universite-paris-saclay.fr
DTSTART:20221118T110000Z
DTEND:20221118T120000Z
DTSTAMP:20221019T094128Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-lea-chazot-franguiadakis/
SUMMARY:Physics-Biology interface seminar: Léa Chazot-Franguiadakis - Moye
 n Amphi\, Building 510\, Université Paris-Saclay Orsay - 18 Nov 22 11:00
DESCRIPTION:Nanofluidics for the study of viral particle transport\nLéa Ch
 azot-Franguiadakis (ENS Lyon)\nFrom a physical point of view\, viruses are
  biological objects with remarkable mechanical and thermodynamic propertie
 s. Their detection and characterisation are currently major public health 
 issues. In this context\, the transport of viruses through nanopores is of
  interest both\nfrom a fundamental and a technological point of view\, as 
 a method to probe viral properties. We use a mimetic approach of a biologi
 cal pore\, the nuclear pore complex\, which is taken by some viruses to ac
 cess the nucleus. It has an exceptional selectivity due to the presence of
  a network of polymers forming a dynamic gel within its central channel. T
 o better understand the characteristics of this transport we build a simpl
 ified and controlled environment based on functionalized nanoporous membra
 nes. The transport of viral particles is studied using an optical detectio
 n method with adjustable specificity. Our device allows real-time detectio
 n of single viral particle transport at the level of a single pore. Our ap
 proach allows us to address technological issues\, such as the quantificat
 ion of virus concentration\, for which we have developed a versatile metho
 d with a low detection limit. It also enables to address fundamental quest
 ions about viruspore interactions. In particular\, we have highlighted an 
 aggregation phenomenon related to the strong confinement of viruses under 
 flow in the nanopore. The modelling of this phenomenon provides access to 
 interaction parameters between the viruses and between the viruses and the
  pore.\n\nMerci de contacter eric.raspaud@universite-paris-saclay.fr et an
 toine.fruleux@universite-paris-saclay.fr si vous désirez rencontrer\nl’
 oratrice/l’orateur ou déjeuner avec nous.
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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