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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-479@lptms.universite-paris-saclay.fr
DTSTART:20170111T110000Z
DTEND:20170111T120000Z
DTSTAMP:20170103T221103Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-leila-perie/
SUMMARY:Physics-Biology interface seminar: Leïla Perié - LPTMS\, salle 20
 1\, 2ème étage\, Bât 100\, Campus d'Orsay - 11 Jan 17 11:00
DESCRIPTION:Deciphering the family of immune cells at the single cell level
 \nLeïla Perié (Institut Curie\, Paris)\n\nHow heterogeneous systems of c
 ells constituting multicellular organisms establish\, organize and achieve
  coordination persists as a central question in natural sciences. Whereas 
 stochastic gene or protein expressions have clearly demonstrated their rol
 e in cellular heterogeneity and are widely studied (Wang and Bodovitz\, 20
 10)\, the role of cell heterogeneity in the organization of multicellular 
 organisms has been less interrogated. Addressing this question requires ad
 equate tools that quantitatively study ensembles of cells individually rat
 her than group of cells.  \n\n\nMy research aims at addressing cell hetero
 geneity in dynamical and complex systems of cells using the hematopoietic 
 system as a model of study. Strikingly hematopoietic cells (immune cells\,
  platelets and red blood cells) compose over 90% of total human cells and 
 correspond to approximately ten trillions of cells (Sender R\, 2016). More
  importantly they all originate from the same cells\, the hematopoietic st
 em cells (HSC)\, through a process called hematopoiesis. In addition\, as 
 immune and blood cells have a short life span (from hours to months) and c
 an response to perturbations like infections\, this process is highly dyna
 mical. It is therefore an interesting and challenging model to study diffe
 rentiation in a complex system at the single cell level. \n\n\nTo achieve 
 this\, Leïla Perié’s lab combines different experimental and mathemati
 cal/computational approaches of single cell tracing to study hematopoiesis
  in vivo. For example cellular barcoding is one of the lineage tracing app
 roaches used by the Perié’s lab. It simultaneously traces the in vivo d
 ifferentiation of individual cells\, allowing to reconstitute the relation
 ship between cell lineages with single cell resolution. In this seminar\, 
 we will discuss some of our recent results using cellular barcoding in hem
 atopoiesis. \n
CATEGORIES:physbio,seminars
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
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  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
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