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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-438@lptms.universite-paris-saclay.fr
DTSTART:20160509T110000Z
DTEND:20160509T120000Z
DTSTAMP:20160430T183511Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-madan-rao/
SUMMARY:Physics-Biology interface seminar: Madan Rao - Moyen Amphi\, Buildi
 ng 510\, Université Paris-Saclay Orsay - 9 Mai 16 11:00
DESCRIPTION:Active Composite Cell Surface - local control of clustering and
  sorting\nMadan Rao (Raman Research Institute &amp\; National Centre for B
 iological Sciences-TIFR\, Bangalore)\n\nThe surface of a living cell needs
  to regulate and control its local composition in a variety of contexts su
 ch as endocytosis and signalling. We have shown that many cell surface mol
 ecules are organised at multiple scales by their coupling to a thin cortic
 al actomyosin layer\, which  actively drives local cell membrane compositi
 on and shape. This includes both transmembrane proteins and lipid anchored
  proteins\, such as GPI-anchored proteins. Crucial to this engagement is t
 he spontaneous emergence of localized contractile platforms in the 2dim ac
 tive cortical fluid. Both the nanoscale clustering and the mesoscale segre
 gation display the unique signatures of activity. We have recently recapit
 ulated many of these effects in a minimal reconstituted system. I will end
  by discussing potential implications of this active composite cell surfac
 e for the processing of cellular information.\n
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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