BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//wp-events-plugin.com//6.4.7.2//EN
TZID:Europe/Paris
X-WR-TIMEZONE:Europe/Paris
BEGIN:VEVENT
UID:0-958@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20240607T110000
DTEND;TZID=Europe/Paris:20240607T120000
DTSTAMP:20240527T140209Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-martin-michael-muller-2/
SUMMARY:Physics-Biology Interface seminar: Martin Michael Müller - Salle d
 es séminaires du FAST et du LPTMS\, bâtiment Pascal n°530 - 7 Juin 24 1
 1:00
DESCRIPTION:Protein-membrane interactions with a twist\nMartin Michael Mül
 ler (U. de Lorraine)\n\nTo understand how a biofilament can interact with 
 a lipid membrane\, mesoscopic models are of particular interest. \nWithin 
 a framework of elasticity theory and geometry\, two mechanisms have been p
 roposed\, which can induce membrane deformations \ndue to a biofilament: t
 he Twister and the Darboux torque mechanism [1]. Whereas the Darboux torqu
 e mechanism has been shown to \nexplain membrane deformations by a polymer
  in several important biological systems\, the Twister mechanism has been 
 studied more \ncarefully only recently [2]. \n\n\nIn my talk I will discus
 s how the Twister mechanism together with numerical simulations can explai
 n the membrane translocation \nof botulinium toxins\, which are among the 
 most powerful toxins produced in nature. The initial deformation of the me
 mbrane by \nthe toxin is caused by the presence of local torques arising f
 rom asymmetric positions of hydrophobic residues. Different\ntorque distri
 butions are observed in the simulations and permit an origin for the mecha
 nism opening the membrane to be proposed.\n\n\n\n[1] J. Fierling et al. So
 ft Matter\, 12:5747\, 2016.\n\n\n[2] A. Delort et al. IJMS\, 25:2481\, 202
 4.\n
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
END:VEVENT
BEGIN:VTIMEZONE
TZID:Europe/Paris
X-LIC-LOCATION:Europe/Paris
BEGIN:DAYLIGHT
DTSTART:20240331T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
END:DAYLIGHT
END:VTIMEZONE
END:VCALENDAR