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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-348@lptms.universite-paris-saclay.fr
DTSTART:20150518T110000Z
DTEND:20150518T120000Z
DTSTAMP:20150504T153805Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-martine-ben-amar/
SUMMARY:Physics-Biology interface seminar: Martine Ben Amar - Moyen Amphi\,
  Building 510\, Université Paris-Saclay Orsay - 18 Mai 15 11:00
DESCRIPTION:Growth of living fibrous tissues: from biofilms to fibrosis\nMa
 rtine Ben Amar (ENS Paris)\nMorphologies of soft materials in growth\, swe
 lling or drying have been extensively studied recently. Shape modification
 s occur as the size varies transforming ordinary spheres\, cylinders and t
 hin plates into more or less complex objects. Existence of fibers exacerba
 tes this complexity\,  giving anisotropy to the growth process itself. The
  growth is coupled to the environment\, for bacteria the substrate\, in pa
 thology the healthy tissue.  In pathological situations  such as  wound-he
 aling or desmoplastic tumor growth\, the  immune system reacts with a batt
 ery of morphogenetic gradients\, making a new tissue full of collagene and
  eventually sending active cells.  All these factors contribute to a  high
  level of compressive stress at the origin of patterns and deformity.  I w
 ill show how we can predict quantitatively  these patterns on the simple d
 rop geometry of the biofilms and on the spherical shape of tumors.\n\nFor 
 the pathological cases\, it turns out that the wrinkling process dominates
  the growth\, deforming the tissues and exacerbating the immune system whi
 ch reacts via passive (fibroblasts) and active cells (myo-fibroblasts).  I
  will show that the consequence is a huge increase of the stiffness\, whic
 h stops spontaneously when the healing is achieved but not in case of impl
 ants or tumors. Naive estimations can be given explaining difficulties enc
 ounted in drug treatments\, for example.\nJoint work with Min Wu.\n
CATEGORIES:seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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