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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-480@lptms.universite-paris-saclay.fr
DTSTART:20170222T110000Z
DTEND:20170222T120000Z
DTSTAMP:20170216T085917Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-michele-castellana/
SUMMARY:Physics-Biology interface seminar: Michele Castellana - LPTMS\, sal
 le 201\, 2ème étage\, Bât 100\, Campus d'Orsay - 22 Fév 17 11:00
DESCRIPTION:Enzyme clustering can induce metabolic channeling\nMichele Cast
 ellana (Institut Curie\, Paris)\nDirect channeling of intermediates via a 
 physical tunnel between enzyme active sites is an established mechanism to
  improve the efficiency of metabolic pathways. In this seminar\, I will pr
 esent a theoretical model which demonstrates that coclustering multiple en
 zymes into proximity can yield the full efficiency benefits of direct chan
 neling. The model predicts the separation and size of coclusters that maxi
 mize metabolic efficiency\, and this prediction is in agreement with the i
 nter-cluster spacing in yeast and mammalian cells. In addition\, the model
  predicts that enzyme agglomerates can regulate steady-state flux division
  at metabolic branch points: we experimentally test this prediction for a 
 fundamental branch point in Escherichia coli bacterium\, and the results c
 onfirm that enzyme colocalization within an agglomerate can accelerate the
  processing of a shared intermediate by one branch. Our studies establish 
 a quantitative framework to understand coclustering-mediated metabolic cha
 nneling\, as well as its application to efficiency improvement and metabol
 ic regulation.
CATEGORIES:physbio,seminars
LOCATION:LPTMS\, salle 201\, 2ème étage\, Bât 100\, Campus d'Orsay\, 15 
 Rue Georges Clemenceau\, Orsay\, 91405\, France
GEO:48.698185;2.181768
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  Orsay\, 91405\, France;X-APPLE-RADIUS=100;X-TITLE=LPTMS\, salle 201\, 2è
 me étage\, Bât 100\, Campus d'Orsay:geo:48.698185,2.181768
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