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TZID:Europe/Paris
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UID:0-1088@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20260417T110000
DTEND;TZID=Europe/Paris:20260417T120000
DTSTAMP:20260402T140155Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-nicolas-dray/
SUMMARY:Physics-Biology Interface seminar: Nicolas Dray - Salle des sémina
 ires du FAST et du LPTMS\, bâtiment Pascal n°530 - 17 Avr 26 11:00
DESCRIPTION:From stem cell interactions to tissue homeostasis: a multiscale
  approach\nNicolas Dray (Institut Pasteur)\nTissue homeostasis relies on t
 he coordinated regulation of stem cell (SC) behaviors\, including self-ren
 ewal\, differentiation\, and quiescence. Yet how stem cell fate decisions 
 are coordinated across space and time to sustain long-term tissue stabilit
 y remains largely unknown.\nWe hypothesize that local cell-cell communicat
 ion through Notch signaling\, coupled with tissue geometry and spatial org
 anization\, gives rise to self-sustained emergent properties at the tissue
  scale. To investigate this question\, we combine experiments\, spatial st
 atistics\, and multiscale modeling in the adult zebrafish pallium\, a rela
 tively simple and accessible system for studying neural stem cell in vivo.
 \nUsing multiplexed smFISH\, immunohistochemistry\, morphometric analysis\
 , and intravital imaging\, we quantify cell states\, fate transitions\, an
 d tissue geometry at single-cell resolution. We are now developing methods
  to infer causal Notch gene regulatory networks from these data and to cha
 racterize stem cell interactions across scales using spatial statistical a
 pproaches.\nI will present our recent progress and discuss our strategy to
  integrate these results into a multiscale model aimed at understanding ho
 w tissue homeostasis and multistability emerge from the interplay between 
 cell-cell signaling\, tissue topology\, and cell fate decisions.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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TZID:Europe/Paris
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DTSTART:20260329T030000
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