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UID:0-1032@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20250516T110000
DTEND;TZID=Europe/Paris:20250516T120000
DTSTAMP:20250515T160105Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-pablo-sartori/
SUMMARY:Physics-Biology Interface seminar: Pablo Sartori - Salle des sémin
 aires du FAST et du LPTMS\, bâtiment Pascal n°530 - 16 Mai 25 11:00
DESCRIPTION:Semantic self-assembly in a meaning-less energy landscape far f
 rom equilibrium (seminar on Zoom)\nPablo Sartori (Gulbenkian Institute for
  Molecular Medicine)\n\nDue to an illness from the speaker\, the seminar h
 as been converted to a remote format - see Zoom link below. Some of us wil
 l gather in the seminar room to watch. Feel free to join us.\n\nLike the l
 etters in the alphabet forming words\, reusing components is an efficient 
 strategy for assembling a large number of target structures from heterogen
 eous mixture of components. Examples range from synthetic DNA origami to p
 roteins self-assembling into complexes. The standard self-assembly paradig
 m views target structures as free-energy minima of a mixture. While this i
 s an appealing picture\, at high speed structures may be kinetically trapp
 ed in local minima\, reducing self-assembly accuracy. How then can high sp
 eed\, high accuracy\, and combinatorial usage of components coexist? We pr
 opose to reconcile these three concepts not by avoiding kinetic traps\, bu
 t by exploiting them to encode target structures. This can be achieved by 
 sculpting the kinetic pathways of the mixture\, instead of its free-energy
  landscape. In other words\, targets structures with semantic value are no
 t enconded in the energy landscape\, but rather on the kinetics. We formal
 ize these ideas in a minimal toy model\, for which we analytically estimat
 e the encoding capacity and kinetic characteristics\, in agreement with si
 mulations. Our results may be generalized to other soft-matter systems cap
 able of computation\, such as liquid mixtures or elastic networks\, and pa
 ve the way for high-dimensional information processing far from equilibriu
 m.\n\n\nTime: May 16\, 2025 11:00 AM Paris\nhttps://cnrs.zoom.us/j/9370119
 1981?pwd=abTkbFq72axppbR2pHUgIumGG6Ojk0.1\nMeeting ID: 937 0119 1981\nPass
 code: Ufwf5x\n
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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