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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-409@lptms.universite-paris-saclay.fr
DTSTART:20160208T110000Z
DTEND:20160208T120000Z
DTSTAMP:20160203T121536Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-paolo-pierobon/
SUMMARY:Physics-Biology interface seminar: Paolo Pierobon - Moyen Amphi\, B
 uilding 510\, Université Paris-Saclay Orsay - 8 Fév 16 11:00
DESCRIPTION:Mechanics of B cell response\nPaolo Pierobon (Institut Curie\, 
 Paris)\nB lymphocytes are the antibodies producing cells and therefore ess
 ential effectors of adaptive immunity. In vivo\, their activation is mostl
 y triggered by the engagement of their B cell receptor (BCR) with antigens
  exposed at the surface of neighbouring antigen presenting cells. This lea
 ds to the formation of a signalling platform\, the immune synapse\, where 
 cytoskeleton rearrangement are essential for the antigen extraction\, inte
 rnalization and processing. While it has been shown that on a hard substra
 te the cell follows a dynamics of spreading and contraction\, this has nev
 er been investigated on substrates with rigidity close to the physiologica
 l one. We measure for the first time the forces produced by B cells on def
 ormable antigen coated surfaces (traction force microscopy) and show that 
 these forces are contractile\, specifically induced by BCR activation and 
 Myosin II dependent. We characterize the contractile dynamics of the cell 
 and argue that in generating pulling forces\, Myosin II plays a crucial ro
 le in antigen gathering and internalization. These results open interestin
 g perspectives on the role of mechanics in the acquisition of specific ant
 igen and more generally on receptor internalization.
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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