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TZID:Europe/Paris
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BEGIN:VEVENT
UID:0-559@lptms.universite-paris-saclay.fr
DTSTART:20171129T110000Z
DTEND:20171129T120000Z
DTSTAMP:20171121T105357Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-pascal-silberzan/
SUMMARY:Physics-Biology interface seminar: Pascal Silberzan - Amphi BLANDIN
  du LPS de la Faculté des Sciences d’Orsay (Bâtiment 510) - 29 Nov 17 
 11:00
DESCRIPTION:Confining and releasing cell monolayers\nPascal Silberzan (Inst
 itut Curie\, Paris)\nCell monolayers routinely exhibit collective behavior
 s largely controlled by cell-cell interactions. In this context\, confinem
 ent and boundary conditions play an important role in the organization and
  dynamics of these cell assemblies. Interestingly\, many in vivo processes
 \, including morphogenesis or tumor maturation\, involve small populations
  of cells within a spatially restricted region.\nWe report experiments in 
 which epithelial monolayers confined in circular disks exhibit low-frequen
 cy periodic radial displacement modes. When the boundary is removed\, cell
 s collectively migrate on the free surface. The essential characteristics 
 of the collective dynamics in these two situations are well-accounted for 
 by the same theoretical model in which cells are described as persistent r
 andom walkers which adapt their motion to that of their neighbors.\n\nIn c
 ontrast\, elongated fibroblasts that do not develop significant cell-cell 
 adhesions self-organize until reaching a perfect nematic order upon confin
 ement in linear stripes. When the cells are confined within a disk\, the n
 umber and charge of the topological defects characteristic of nematics can
  be controlled\, emphasizing the role of friction in this active nematic s
 ystem.\n\nAfter days in culture\, the confined epithelia develop a tridime
 nsional structure in the form of a peripheral cell cord at the domain edge
 . Confinement by itself is therefore sufficient to induce morphogenetic-li
 ke processes including spontaneous collective pulsations\, global orientat
 ion and transition from 2D to 3D. \n
CATEGORIES:physbio,seminars
LOCATION:Amphi BLANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtim
 ent 510)\, 15 Rue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Amphi BLANDIN du LPS de la Facu
 lté des Sciences d’Orsay (Bâtiment 510):geo:48.698187,2.181768
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