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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-539@lptms.universite-paris-saclay.fr
DTSTART:20171018T110000Z
DTEND:20171018T120000Z
DTSTAMP:20171005T121757Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-paul-francois/
SUMMARY:Physics-Biology interface seminar: Paul François - Amphi BLANDIN d
 u LPS de la Faculté des Sciences d’Orsay (Bâtiment 510) - 18 Oct 17 11
 :00
DESCRIPTION:Untangling the biological hairball of immune recognition networ
 ks\nPaul François (McGill University\, Canada)\n\nComplex mathematical mo
 dels of interaction networks are routinely used for prediction in systems 
 biology. However\, it is difficult to reconcile network complexities with 
 a formal understanding of their behavior.  I will introduce several models
  of immune recognition by T cells and will show how a simple procedure can
  be used  to reduce them to functional submodules\, using statistical mech
 anics of complex systems combined with a fitness-based approach inspired b
 y in silico evolution. Our procedure works by putting parameters or combin
 ation of parameters to some asymptotic limit\, while keeping (or slightly 
 improving) the model performance\, and requires parameter symmetry breakin
 g for more complex models. An intractable model of immune recognition with
  close to a hundred individual transition rates is reduced to a simple two
 -parameter model\, and connected to the ``adaptive sorting" principle that
  we previously identified and experimentally validated. Our procedure extr
 acts three different mechanisms for early immune recognition\, and automat
 ically discovers similar functional modules in different models of the sam
 e process allowing for model classification and comparison. \n
CATEGORIES:physbio,seminars
LOCATION:Amphi BLANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtim
 ent 510)\, 15 Rue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Amphi BLANDIN du LPS de la Facu
 lté des Sciences d’Orsay (Bâtiment 510):geo:48.698187,2.181768
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