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TZID:Europe/Paris
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BEGIN:VEVENT
UID:0-546@lptms.universite-paris-saclay.fr
DTSTART:20180207T110000Z
DTEND:20180207T120000Z
DTSTAMP:20180130T181628Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-pere-roca-cusachs/
SUMMARY:Physics-Biology interface seminar: Pere Roca-Cusachs - Amphi BLANDI
 N du LPS de la Faculté des Sciences d’Orsay (Bâtiment 510) - 7 Fév 18
  11:00
DESCRIPTION:Sensing the matrix: transducing mechanical signals from integri
 ns to the nucleus.\nPere Roca-Cusachs (Institute for Bioengineering of Cat
 alonia\, Universitat de Barcelona\, Spain)\nCell proliferation and differe
 ntiation\, as well as key processes in development\, tumorigenesis\, and w
 ound healing\, are strongly determined by the properties of the extracellu
 lar matrix (ECM)\, including its mechanical rigidity and the density and d
 istribution of its ligands. In this talk\, I will explain how we combine m
 olecular biology\, biophysical measurements\, and theoretical modelling to
  understand the mechanisms by which cells sense and respond to matrix prop
 erties. I will discuss how the properties under force of integrin-ECM bond
 s\, and of the adaptor protein talin\, drive and regulate matrix sensing. 
 I will further discuss how this sensing can be understood through a comput
 ational molecular clutch model\, which can quantitatively predict the role
  of integrins\, talin\, myosin\, and ECM receptors\, and their effect on c
 ell response. Finally\, I will analyze how signals triggered by rigidity a
 t cell-ECM adhesions are transmitted to the nucleus\, leading to the activ
 ation of the transcriptional regulator YAP.
CATEGORIES:physbio,seminars
LOCATION:Amphi BLANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtim
 ent 510)\, 15 Rue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Amphi BLANDIN du LPS de la Facu
 lté des Sciences d’Orsay (Bâtiment 510):geo:48.698187,2.181768
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