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TZID:Europe/Paris
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BEGIN:VEVENT
UID:0-625@lptms.universite-paris-saclay.fr
DTSTART:20181017T110000Z
DTEND:20181017T120000Z
DTSTAMP:20181012T062142Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-pierre-ronceray/
SUMMARY:Physics-Biology interface seminar: Pierre Ronceray - Amphi BLANDIN 
 du LPS de la Faculté des Sciences d’Orsay (Bâtiment 510) - 17 Oct 18 1
 1:00
DESCRIPTION:Cell contraction induces long-ranged stress stiffening in the e
 xtracellular matrix\nPierre Ronceray (Princeton University\, USA)\nAnimal 
 cells in tissues are supported by biopolymer matrices\, which typically ex
 hibit highly nonlinear mechanical properties. While the linear elasticity 
 of the matrix can significantly impact cell mechanics and functionality\, 
 it remains largely unknown how cells\, in turn\, affect the nonlinear mech
 anics of their surrounding matrix. Here we show that living contractile ce
 lls are able to generate a massive stiffness gradient in three distinct 3D
  extracellular matrix model systems: collagen\, fibrin\, and Matrigel. We 
 decipher this remarkable behavior by introducing Nonlinear Stress Inferenc
 e Microscopy (NSIM)\, a novel technique to infer stress fields in a 3D mat
 rix from nonlinear microrheology measurement with optical tweezers. Using 
 NSIM and simulations\, we reveal a long-ranged propagation of cell-generat
 ed stresses resulting from local filament buckling. This slow decay of str
 ess gives rise to the large spatial extent of the observed cell-induced ma
 trix stiffness gradient\, which could form a mechanism for mechanical comm
 unication between cells.
CATEGORIES:physbio,seminars
LOCATION:Amphi BLANDIN du LPS de la Faculté des Sciences d’Orsay (Bâtim
 ent 510)\, 15 Rue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=15 Rue Georges Clemenceau\,
  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Amphi BLANDIN du LPS de la Facu
 lté des Sciences d’Orsay (Bâtiment 510):geo:48.698187,2.181768
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