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TZID:Europe/Paris
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BEGIN:VEVENT
UID:0-817@lptms.universite-paris-saclay.fr
DTSTART:20220316T110000Z
DTEND:20220316T120000Z
DTSTAMP:20220221T095253Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-ram-adar/
SUMMARY:Physics-Biology interface seminar: Ram Adar - Salle des séminaires
  du FAST et du LPTMS\, bâtiment Pascal n°530 - 16 Mar 22 11:00
DESCRIPTION:Active-gel Theory for Multicellular Migration in the Extra-cell
 ular Matrix\nRam Adar (Collège de France)\nWe formulate an active-gel the
 ory for multicellular migration in the extracellular\nmatrix (ECM). The ce
 lls are modeled as an active\, polar solvent\, and the\nECM as a viscoelas
 tic solid. Our theory enables to analyze the dynamic reciprocity\nbetween 
 the migrating cells and their environment in terms of distinct relative fo
 rces\nand alignment mechanisms. We analyze the linear stability of polar c
 ells migrating\nhomogeneously in the ECM. Our theory predicts that\, as a 
 consequence of cell-matrix\nalignment\, contractile cells migrate homogene
 ously for small wave vectors\, while\nsufficiently extensile cells migrate
  in domains. Homogeneous cell migration of both\nextensile and contractile
  cells may be unstable for larger wave vectors\, due to active\nforces and
  the alignment of cells with their concentration gradient. These mechanism
 s\nare stabilized by cellular alignment to the migration flow and matrix s
 tiffness. They\nare expected to be suppressed entirely for rigid matrices 
 with elastic moduli of order\n10 kPa. Our theory should be useful in analy
 zing multicellular migration and ECM\npatterning at the mesoscopic scale.
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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