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TZID:Europe/Paris
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BEGIN:VEVENT
UID:1-368@lptms.universite-paris-saclay.fr
DTSTART:20151102T110000Z
DTEND:20151102T120000Z
DTSTAMP:20151030T110046Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-romain-koszul/
SUMMARY:Physics-Biology interface seminar: Romain Koszul - Moyen Amphi\, Bu
 ilding 510\, Université Paris-Saclay Orsay - 2 Nov 15 11:00
DESCRIPTION:Insights on the regulatory principles of genome organization in
  unicellular microorganisms\nRomain Koszul (Institut Pasteur)\n\nChromosom
 es of a broad range of kingdoms\, from bacteria to mammals\, are structure
 d by large topological domains\, whose precise functional roles and regula
 tory mechanisms remain elusive. Using chromosome conformation capture tech
 nology\, we unraveled the higher-order organization of the Bacillus subtil
 is\, Escherichia coli and Vibrio cholerae genomes\, in a variety of growth
  and mutant conditions. Different types of topological domains were found 
 to structure these chromosomes\, ranging from a few dozens to a thousand k
 b. We show that the matP/matS and parB/parS systems generate specific type
 s of topological structures\, regulated by replication and cell cycle prog
 ression. We have also functionally characterized some of the global organi
 zational principles of these domains\, in link with replication/segregatio
 n during the cell cycle. Overall\, the comparative analysis of these diffe
 rent species provide striking insights on the diversity of the regulatory 
 mechanisms of genome structure of the bacterial world.  In addition\, I wi
 ll also present and discuss recent data obtained during the cell cycle of 
 the eukaryotic species Saccharomyces cerevisiae.\n
CATEGORIES:physbio,seminars
LOCATION:Moyen Amphi\, Building 510\, Université Paris-Saclay Orsay\, 15 R
 ue Georges Clemenceau\, orsay\, France
GEO:48.698187;2.181768
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  orsay\, France;X-APPLE-RADIUS=100;X-TITLE=Moyen Amphi\, Building 510\, Un
 iversité Paris-Saclay Orsay:geo:48.698187,2.181768
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