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TZID:Europe/Paris
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BEGIN:VEVENT
UID:0-711@lptms.universite-paris-saclay.fr
DTSTART:20200115T110000Z
DTEND:20200115T120000Z
DTSTAMP:20191014T193906Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-ronald-melki/
SUMMARY:Physics-Biology interface seminar: Ronald Melki - Salle des sémina
 ires du FAST et du LPTMS\, bâtiment Pascal n°530 - 15 Jan 20 11:00
DESCRIPTION:Prion-like propagation of alpha-synuclein assemblies in synucle
 inopathies\, similarities with Tau in Tauopathies\nRonald Melki (Institut 
 François Jacob\, CEA &amp\; CNRS)\nThe aggregation of proteins within the
  central nervous system is deleterious and associated to neurodegenerative
  disorders. The aggregation of the proteins alpha-synuclein and Tau are as
 sociated to synucleinopathies\, in particular Parkinson's disease\, and ta
 uopathies\, among which Alzheimer’s disease\, respectively. How alpha-sy
 nuclein and Tau aggregates\, how those aggregates traffic between cells\, 
 amplify by recruiting endogenous monomeric alpha-synuclein or Tau and caus
 e distinct synucleinopathies or tauopathies is unclear.\n\nI will explain 
 the molecular events that lead to alpha-synuclein or Tau aggregation. I wi
 ll show that alpha-synuclein and Tau aggregates bind to neurons cell membr
 anes and explain the cellular consequences of binding. The similarities an
 d differences between alpha-synuclein and Tau will be highlighted. I will 
 explain how alpha-synuclein and Tau aggregates penetrate the cells and get
  transported. Finally\, I will describe how the structure of the fibrillar
  polymorphs alpha-synuclein and Tau aggregation yield distinct diseases.\n
 \nReferences:\n\nBrundin P et al. (2010) Nat Rev Mol Cell Biol. 11:301-7.\
 nBousset L et al. (2013) Nat Commun. 4:2575.\nPeelaerts W et al. (2015) Na
 ture 522:340-4.\nShrivastava AN et al. (2015) EMBO J. 34:2408-23.\nBrahic 
 M et al. (2016) Acta Neuropathol. 131:539-48.\nMakky A et al. (2016) Sci R
 ep. 6:37970.\nFlavin W et al. (2017) Acta Neuropathol. 134:629-653.\nShriv
 astava AN et al. (2017) Neuron 95:33-50.\nMelki R (2018) Neurobiol Dis. 10
 9:201-208.\nGribaudo S et al. (2019) Stem Cell Reports. 12:230-244.\nShriv
 astava AN et al. (2019) EMBO J. 38. pii: e99871.\nFenyi A et al.\, (2019) 
 Neurobiol Dis 129:38-43.\n
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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