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UID:0-946@lptms.universite-paris-saclay.fr
DTSTART;TZID=Europe/Paris:20240329T110000
DTEND;TZID=Europe/Paris:20240329T120000
DTSTAMP:20240219T090810Z
URL:http://www.lptms.universite-paris-saclay.fr/seminars/physics-biology-i
 nterface-seminar-russell-spencer/
SUMMARY:Physics-Biology Interface Seminar: Russell Spencer - Salle des sém
 inaires du FAST et du LPTMS\, bâtiment Pascal n°530 - 29 Mar 24 11:00
DESCRIPTION:Exploring Membrane Topology Transformations using Polymer Field
  Theory\nRussell Spencer (University of Göttingen)\n\nMembrane remodeling
 \, including fusion and fission\, plays a crucial role in various cellular
  processes. However\, understanding the intricacies of these topological c
 hanges can be challenging due to the involvement of large-scale membrane r
 earrangements and their sensitivity to small-scale molecular behavior. Mor
 eover\, these remodeling events face significant free-energy barriers that
  necessitate the presence of catalytic proteins. In this work\, we utilize
  self-consistent field theory (SCFT) in combination with the string method
  to identify the Minimum Free Energy Path (MFEP). We thereby determine the
  most probable pathway for specific remodeling transitions implicated in c
 ellular signaling and organelle division. This approach has allowed us to 
 discover a new pathway by which the fusion of membranes may catalyze their
  fission. Furthermore\, we extend conventional SCFT methods\, introducing 
 proteins inspired by the dynamin family. These proteins facilitate fission
  by constricting membrane tubes. We find that the free energy barrier to f
 ission depends strongly on membrane tension and constriction. In addition 
 to simply constricting the membrane\, dynamin's PH domains are inserted be
 tween lipid head groups\, inducing membrane distortion. Our results emphas
 ize the crucial role of this distortion in reducing the free energy barrie
 r to fission. This research sheds light on the underlying mechanisms of me
 mbrane remodeling and provide insights into cellular processes involving t
 opological changes.\n
CATEGORIES:physbio,seminars
LOCATION:Salle des séminaires du FAST et du LPTMS\, bâtiment Pascal n°53
 0\, rue André Riviere\, Orsay\, 91405\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=rue André Riviere\, Orsay\
 , 91405\, France;X-APPLE-RADIUS=100;X-TITLE=Salle des séminaires du FAST 
 et du LPTMS\, bâtiment Pascal n°530:geo:0,0
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DTSTART:20231029T020000
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